Storybook Wedding Autographed, by Kj Micciche

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This contributed volume presents an overview of concepts, methods, and applications used in several quantitative areas of drug research, development, and marketing. Chapters bring together the theories and applications of various disciplines, allowing readers to learn more about quantitative fields, and to better recognize the differences between them. Because it provides a thorough overview, this will serve as a self-contained resource for readers interested in the pharmaceutical industry, and the quantitative methods that serve as its foundation. Specific disciplines covered include: Biostatistics Pharmacometrics Genomics Bioinformatics Pharmacoepidemiology Commercial analytics Operational analytics Quantitative Methods in Pharmaceutical Research and Development is ideal for undergraduate students interested in learning about real-world applications of quantitative methods, and the potential career options open to them. It will also be of interest to experts working in these areas.

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This book arose from a conference on “Singularities and Computer Algebra” which was held at the Pfalz-Akademie Lambrecht in June 2015 in honor of Gert-Martin Greuel’s 70th birthday. This unique volume presents a collection of recent original research by some of the leading figures in singularity theory on a broad range of topics including topological and algebraic aspects, classification problems, deformation theory and resolution of singularities. At the same time, the articles highlight a variety of techniques, ranging from theoretical methods to practical tools from computer algebra. Greuel himself made major contributions to the development of both singularity theory and computer algebra. With Gerhard Pfister and Hans Schönemann, he developed the computer algebra system SINGULAR, which has since become the computational tool of choice for many singularity theorists. The book addresses researchers whose work involves singularity theory and computer algebra from the PhD to expert level.

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This book provides an overview of different topics related to the theory of partial differential equations. Selected exercises are included at the end of each chapter to prepare readers for the “research project for beginners” proposed at the end of the book. It is a valuable resource for advanced graduates and undergraduate students who are interested in specializing in this area. The book is organized in five parts: In Part 1 the authors review the basics and the mathematical prerequisites, presenting two of the most fundamental results in the theory of partial differential equations: the Cauchy-Kovalevskaja theorem and Holmgren's uniqueness theorem in its classical and abstract form. It also introduces the method of characteristics in detail and applies this method to the study of Burger's equation. Part 2 focuses on qualitative properties of solutions to basic partial differential equations, explaining the usual properties of solutions to elliptic, parabolic and hyperbolic equations for the archetypes Laplace equation, heat equation and wave equation as well as the different features of each theory. It also discusses the notion of energy of solutions, a highly effective tool for the treatment of non-stationary or evolution models and shows how to define energies for different models. Part 3 demonstrates how phase space analysis and interpolation techniques are used to prove decay estimates for solutions on and away from the conjugate line. It also examines how terms of lower order (mass or dissipation) or additional regularity of the data may influence expected results. Part 4 addresses semilinear models with power type non-linearity of source and absorbing type in order to determine critical exponents: two well-known critical exponents, the Fujita exponent and the Strauss exponent come into play. Depending on concrete models these critical exponents divide the range of admissible powers in classes which make it possible toprove quite different qualitative properties of solutions, for example, the stability of the zero solution or blow-up behavior of local (in time) solutions. The last part features selected research projects and general background material.

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  Now in its third decade, the Colorado Mathematical Olympiad (CMO), founded by the author, has become an annual state-wide competition, hosting many hundreds of middle and high school contestants each year. This book presents a year-by-year history of the CMO from 2004–2013 with all the problems from the competitions and their solutions. Additionally, the book includes 10 further explorations, bridges from solved Olympiad problems to ‘real’ mathematics, bringing young readers to the forefront of various fields of mathematics. This book contains more than just problems, solutions, and event statistics — it tells a compelling story involving the lives of those who have been part of the Olympiad, their reminiscences of the past and successes of the present. I am almost speechless facing the ingenuity and inventiveness demonstrated in the problems proposed in the third decade of these Olympics. However, equally impressive is the drive and persistence of the originator and living soul of them. It is hard for me to imagine the enthusiasm and commitment needed to work singlehandedly on such an endeavor over several decades. <—Branko Grünbaum, University of Washington After decades of hunting for Olympiad problems, and struggling to create Olympiad problems, he has become an extraordinary connoisseur and creator of Olympiad problems.  The Olympiad problems were very good, from the beginning, but in the third decade the problems have become extraordinarily good.  Every brace of 5 problems is a work of art.  The harder individual problems range in quality from brilliant to work-of-genius… The same goes for the “Further Explorations” part of the book.  Great mathematics and mathematical questions are immersed in a sauce of fascinating anecdote and reminiscence.  If you could have only one book to enjoy while stranded on a desert island, this would be a good choice.   Like Gauss, Alexander Soifer would not hesitate to inject Eureka! at the right moment. Like van der Waerden, he can transform a dispassionate exercise in logic into a compelling account of sudden insights and ultimate triumph. — Cecil Rousseau Chair, USA Mathematical Olympiad Committee A delightful feature of the book is that in the second part more related problems are discussed. Some of them are still unsolved. —Paul Erdős The book is a gold mine of brilliant reasoning with special emphasis on the power and beauty of coloring proofs. Strongly recommended to both serious and recreational mathematicians on all levels of expertise. —Martin Gardner

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Overtone Singing is the most comprehensive book ever written on the hidden harmonies of the human voice. Ethnomusicologist and vocalist Mark van Tongeren offers fascinating insights into the timeless and universal aspects of sound and vibration. Grounded in the author's decade-long study of Asian music, the book draws upon field work, interviews with Eastern and Western musicians, and copious scholarship to present a multidisciplinary vision of sound that runs from global music to the science of acoustics and perception, onward to the philosophical and spiritual dimensions of music. Written in a nontechnical style, this generously illustrated book is an indispensable guide for musicians, listeners, and performers seeking a deeper understanding of the nature of the human voice and its harmonic possibilities from East to West.

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