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Explore the search for objective biomarkers in Schizophrenia Spectrum Disorders with this comprehensive research guide. The book covers evolving pathophysiological hypotheses including neurotrophic, neurotransmitter, immune-inflammatory, and metabolic theories that drive biomarker discovery. Learn how receiver operating characteristic (ROC) analysis helps develop predictive, diagnostic, and theranostic models for more accurate clinical assessment. Practical chapters include step-by-step guidance on using the MetaboAnalyst platform with clear statistical interpretation methods. This resource is essential for researchers, clinicians, and students seeking data-driven approaches to improve schizophrenia diagnosis and treatment strategies. Advance your understanding of systemic biological changes and contribute to more reliable psychiatric diagnostics.