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5-HTP, the intermediate metabolite between the amino acid L-tryptophan and serotonin, is extracted from the seed of an African plant (Griffonia simplicifolia). 5-HTP readily crosses the blood-brain barrier and increases central nervous system (CNS) synthesis of serotonin. Serotonin can affect sleep, and many other important biological functions. This is a mid-range dosage of 5-HTP. NOW® natural and organic Supplements are an effective way to ensure you and your loved ones are getting essential vitamins, minerals and nutrients for daily optimal health. Since 1968, NOW has been making top quality products that are tested to the highest standards to empower people to lead healthier lives. Now's promise - what is on the label, is precisely what is in the bottle.Recommended Dosage: Adult Dosage: Fibromyalgia: Take 1 capsule 3-4 times daily with food. Use for a minimum of 2 weeks to see beneficial effects. Consult a health care practitioner for use beyond one year. Migraines: Take 1-2 capsules 2-3 times daily with food. Use for a minimum of 2-3 weeks to see beneficial effects. Consult a health care practitioner for use beyond 6 months. To minimize the risk of gastrointestinal side effects, start with 1 capsule, 2-3 times per day and slowly increase to 2 capsules over a 2 week period.Caution: Consult a health care practitioner prior to use if you are pregnant or breastfeeding or if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John's wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Consult a health care practitioner if symptoms persist or worsen. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain, or if you experience skin changes. Do not use if you have scleroderma. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Some people may experience diarrhea, nausea, vomiting, abdominal pain and drowsiness.